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The possible harm of increased lung edema was investigated by Martin and colleagues [ 23].
This differential increase in cumulative probability of death emphasises the central role of tobacco as a risk factor for mortality, as well as the potential extra harm of increased alcohol consumption.
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Clinicians and patients need to balance any benefit from using ibuprofen against the possible harm of increasing reconsultations with poorly controlled symptoms and a small risk of complications.
Concerns about potential harm of increasing vitreoretinal traction owing to rapid neovascular involution with fibrosis contraction by IVB pretreatment must be raised.
These provocative findings [ 5] (and similar work by Pàez-Ribes and colleagues [ 9]) suggest that in trying to do good with adjuvant anti-VEGF therapy we might create the great harm of increasing distant metastatic disease.
Disclosing all the information has the potential to cause harm because of increased (and possibly unwarranted) worry and anxiety [ 9, 34], yet it was evident that obstetricians in this study were very supportive of women's autonomy and self-determination and therefore their need for full information disclosure.
As a result, minority borrowers who were steered into subprime loans paid, on average, thousands of dollars more for their loans and experienced additional harm as a result of increased risk of prepayment penalties, credit problems, default and ultimately foreclosure.
Initial reports also identified that participants were concerned about the potential reaction that their communities may have to the news given the previous media coverage of the Cellulose Sulphate trial being initially stopped due to a risk of increased harm.
Moreover, the recent large-scale, multicenter trials (REDOXS and MetaPlus) show no benefits, but instead indicate signals of increased harm with respect to long-term mortality.
Within this larger context, the risk of increased violence, harm to civilian populations and further humanitarian suffering is very real.
Some groups state or strongly imply that the presence in the body of any level of manmade chemicals is evidence of increased risk of harm [ 13- 15].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com