Sentence examples for harm burden from inspiring English sources

Second, the evidence needed to trade off benefits and downsides (harm, burden and cost) of options may be of low quality.

The GRADE guidance available at the time of developing this guidance did not provide an objective method for assessing the balance between benefit, harm, burden, values, and costs [ 13, 17].

If we are confident that benefits do or do not outweigh harms, burden, and costs, we make a strong recommendation in our formulation, Grade 1.

In the paper by Keller and colleagues, reporting only adverse events that occurred in more than 5% of patients obscured the harms burden.

Groups making recommendations always make judgements about the quality of evidence and the balance of benefits and downsides (harms, burden and costs).

The key question is at which cut-off value the magnitude of benefits (possible the early detection of CRC or the removal of adenomas) is sufficient to outweigh the harms (burden, complications, demand on colonoscopy capacity and costs of screening).

Despite the lack of stronger direct evidence, there is agreement among most guideline developers that grading the quality of evidence has advantages, because health care decisions involve a trade-off between likely benefits on the one hand, and downsides (harms, burden and costs) on the other hand [ 40].

We determine the strength of a recommendation by considering the balance between the desirable effects of an intervention and the undesirable effects (incremental harms, burdens, and for select recommendations, costs).

Falls, road traffic accidents and self-harm were each responsible for 20-30% of the entire injury burden.

and (3) the guarantee of only minimal harm and burden in the study (are additional blood-taking and study examinations acceptable to the children?).

His main research foci include global alcohol and prescription opioid use and harm epidemiology; burden of disease and evaluation of interventions and policy for substance use.