It hails from Alaska and is supposed to be ridiculously hardy; a subject for a gravelly bed or alpine trough maybe?
Two investigators (Niu and Deng) independently extracted the following data from each included study: the first author's name, publication date, country, ethnicity (categorized as Asian, Caucasian, and mixed race), study design, number of cases and controls subjects, Hardy-Weinberg equilibrium (HWE), minor allele frequency (MAF), and cancer location.
His subjects were hardy, working-class types, with broad faces and wide-set eyes, seen in repose on the waterways — stock, if languid, genre scenes that implied the picturesque taming of the Wild West.
For each simulation run, 1000 haplotypes were randomly drawn given the haplotype frequency distribution thus creating two copies of the haplotypes for 500 subjects assuming Hardy-Weinberg equilibrium.
A chi-square test was used to test genotype frequencies in control subjects for Hardy-Weinberg equilibrium (HWE) by comparing observed genotype frequencies with those expected under HWE.
Genotypes were checked for Mendelian inheritance errors using FBAT [23] and PEDSTATS was used to discard SNPs which deviate from Hardy-Weinberg Equilibrium in unrelated subjects [44].
Our study has several strengths like all our control subjects were under Hardy-Weinberg equilibrium minimizing population stratification, all our cases were histopathologically confirmed minimizing misclassification of outcome and cases and controls were matched for age and gender.
The χ test was used to determine Hardy-Weinberg equilibrium among control subjects.
Our study has several strengths, including high participation levels of eligible cases from a homogeneous population of similar ancestry and all of our control subjects being under Hardy-Weinberg equilibrium.
We also assessed the deviation of Hardy-Weinberg equilibrium in control subjects, and the results demonstrated that all the genotype distributions in the control groups had high goodness-of-fit.
