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Results of an nBLAST experiment are consistent with this finding and indicate a high conservation score (>70) for left stem and main stem; whereas major loop, right stem, cap and major loop right half were hardly conserved.
Moreover, all so far described features seemed to be hardly conserved in related genomes.
The gene structures of CrGPx genes are hardly conserved (Fig. 15).
While several of the new mutations are found in antigenic regions, it is also apparent that they often occur on positions that are hardly conserved among different NA subtypes.
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This year, we're hardly conserving at all — just 1%.
As expected, short stretches (2 4 identical residues) hardly yielded conserved genes, while with longer (10 residues) regions only conserved sequences were found, both with and without an intron.
This seems to be best compatible with the hypothesis that protein evolution largely depends on the simple physics of folding (baseline selection, indeed) than on functional features of proteins like pleiotropy which hardly can be universally conserved.
As correctly pointed out by Dr. Koonin, the true alternative hypothesis of the gene pleiotropy hypothesis is the hypothesis of 'molecular biophysics', that is, "protein evolution largely depends on the simple physics of folding (baseline selection, indeed) than on functional features of proteins like pleiotropy which hardly can be universally conserved".
In fact, Robert A. Lutz, vice chairman of General Motors, said last week that the average car buyer hardly cares about conserving gasoline, because it's so cheap.
In contrast, conserved gene order is hardly distinguishable between Waddlia and Chlamydia.
The genome of F. tularensis subsp. holarctica is highly conserved and strains can hardly be discriminated.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com