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Such proteins have been designated as "hard" cases to assign structural folds or functions.
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It's a hard case to make.
But that's a hard case to make.
It has been a hard case to make.
But it's a hard case to argue.
They will have to make their case and it's a hard case to make.
It would be a hard case to make, even if her copyright has technically been infringed.
"On the terrorism side, I think he has a very hard case to make".
There is no question that it would be a very hard case to make".
A player revolt against the coach was not a hard case to lay out.
This will be a hard case to make in Congress and the courts.
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