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He is a heterozygote carrier of the NOD2 R702W variant that is associated with a twofold increase in odds ratio of CD. 29 In addition he harbours potentially damaging mutations in GSDMB and ZNF365 and a dinucleotide variant of undetermined functionality on one chromosomal copy of the IL18RAP gene.
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In normal cells, the DDR emanating from uncapped telomeres leads to irreversible cell cycle arrest or cell death, thus limiting the proliferative potential of cells harbouring potentially deleterious mutations.
Such a situation harbour potentially adverse ramifications on the future food security and overall agricultural productivity, amidst the burgeoning populations in Kenya, as is the case in other developing countries.
Such increasing climatic shifts have been shown to harbour potentially adverse implications on food security through the impact on crop output in Kenya and other parts of the developing world (Campbell et al. 2016; Cohn et al. 2016; Oluoko-Odingo 2011; Rigolot et al. 2017; Silvestri et al. 2015; Wambua and Omoke 2014).
They may do so by phagocytosis of apoptotic cells harbouring potentially pro-inflammatory and harmful effects on the fetus (reviewed in [6]).
It has been established that many families with hereditary non-polyposis colorectal cancer (HNPCC) harbour potentially pathogenic mutations in MMR genes, particularly in hMLH1 and hMSH2 [ 3].
Anaesthetists will be involved in the care of patients who may harbour potentially pathogenic organisms, which may not be obvious or readily identifiable.
> -wrap-foot> We analysed CNVs that were present in regions of the genome that are regarded as harbouring potentially pathogenic CNVs that increase the risk of schizophrenia, autism, mental retardation and/or epilepsy (14), as shown in Table 3.
Our results indicate that not only are tributaries isolated and harbour potentially locally adapted populations but they are also the most vulnerable to population crashes due to natural or human-induced causes even when the total number of salmon entering and being harvested in the Teno system is very large.
Both patients harboured other potentially damaging mutations in the GSDMB, ERAP2 and SEC16A genes.
We could observe a significant higher immunohistochemical expression of c-KIT in mucosal melanomas that harbour a potentially activating KIT mutation as compared with tumours without KIT mutation.
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