In summary, we demonstrate that genetic background plays an important role in modulating the effect of inactivation of GSK-3α on insulin responsiveness and that mice harbouring tissue-specific inactivation of GSK-3α in skeletal muscle and liver tissues display normal insulin sensitivity.
The main aspect that the theoretical models have investigated so far is how proliferation-induced mutations can affect the function of the tissue and the survival of the individual harbouring the tissue in the context of cancer.
In mice harbouring a tissue-specific deletion of Gata4 in the gut, jejunal gene expression was noted to change to the ileal-type, underscoring the role of GATA-4 in the development of the proximal small intestine [ 11].
The tissue sections also harboured unaffected tissue, leading to the dilution of virus-containing cells.
Furthermore, we assume that all tissues harbouring HIV are exposed to the same concentration of drug.
The functional differentiation and adaptability to different environments of cells and tissues harbouring the same genetic material are dependent on epigenetic regulation at different levels.
Past studies using preclinical models have indicated specific toxicity only in tissues harbouring wild-type p53 during cytotoxic therapy (Komarov et al, 1999).
We used PCR analysis on a panel of mouse tissue cDNAs with primers for sAC-HD and sAC-C2 to confirm the presence of sAC-HD in testis and to identify other tissues harbouring HD-containing sAC isoforms.
In other transcriptomic studies of birds, very few endoparasite transcripts have so far been found, presumably due to the fact that the main organs or tissues harbouring the parasites have not been sampled [ 55, 56].
In the context of HIV infection, the increased proportion of activated platelets T-cell conjugate suggest that these cells are more platelets T-cell into inflamed tissues harbouring HIV repliconjugate
However, implantation sites of significantly smaller size harbouring extra-embryonic tissue with no traceable residual embryonic tissue were found, indicating lethality before E9.5 (Fig. 1G).
