The amplification on 13q appears to harbour candidate genes that may confer a more aggressive phenotype to colorectal cancer cells.
The X block in A6 contained QTL for days to bolting and harboured candidate gene LEAFY and mads affecting flowering time 3.
These novel CNV regions, which harbour candidate genes that possibly contribute to phenotypic variation in dogs or to disease-susceptibility, are a rich resource for future investigations.
For example, a narrow region on the q-arm of chromosome 1 proximal to the centromere (1q21-23) is predicted to be frequently amplified both by IR.CGMA and aCGH, suggesting that this region may harbour candidate oncogenes.
This study reports genomic regions detected as being concordant across breeds, which putatively harbour candidate genes that influence tenderness and which could be targeted for the development of diagnostic assays.
Among the T1D genomic risk loci identified by genome-wide association studies, at least six harbour candidate genes that have been implicated directly in B cell differentiation and function (PTPN22, BACH2, PTPN2, IL2 IL21, IL10 and SH2B3; http://www.T1DBase.org).org
A total of 42 NHL cases, 21 DLBCL and 21 FL, were analysed using a high resolution LOH approach, which identified 46 common LOH regions across FL and DLBCL cases, harbouring 262 candidate tumour suppressor genes [ 8].
In the present study, several genomic regions that harbour candidate drug resistance genes in the GLC4-MITO were located.
ArrayCGH has been proven to be a valuable screening method for evaluation of the chromosome alterations and for delineation of possible deletion events, allowing fine-mapping of the candidate regions that harbour candidate suppressor genes.
Genome scans confirmed the presence of selective sweeps in the genomic regions that harbour candidate genes that are known to affect productive traits in cattle such as DGAT1, ABCG2, CAPN3, MSTN and FTO.
