Thus, these tagging SNPs may mark regions of the genome that harbor risk alleles for breast cancer.
Thus, genetic markers act as signposts to regions of the genome that are likely to harbor risk genes.
Although there are different blocks of linkage disequilibrium that harbor risk variants, cancer clustering might suggests the existence of a common molecular mechanism of susceptibility.
In summary, single-SNP, multi-SNP, and haplotype analyses do not indicate that NFKBIA or NFKBIB harbor risk alleles for ovarian cancer.
However, the possibility that individuals who are RP or LTNP harbor risk alleles that are unique to each tail in the distribution cannot be discounted.
We examined only families in the class Mammalia that have been shown to harbor risk zoonoses; however, many pathogens routinely cross boundaries at least as high as the class level (e.g., human psittacosis from birds), if not higher.
The present analysis is an early epidemiologic assessment which indicates that NFKBIA and NFKBIB are not likely to harbor risk alleles under our statistical assumptions; the key limitation of our study is its focus on only two genes.
Our findings suggest that these tagging SNPs in HSD11B1 and IRS2 mark regions of the genome that may harbor risk alleles for breast cancer, and these associations are probably independent of adiposity.
Therefore, determining if any of the large set of enhancers that harbor risk-associated SNPs are also in eQTL with one or more genes may identify a subset of risk-associated enhancers that have a higher probability of having an impact on gene expression.
A strong, healthy heart is less susceptible to cardiovascular disease, and a strong, healthy body is less likely to harbor risk factors such as obesity or high cholesterol / blood pressure / blood sugar.
