Sentence examples for harbor kit from inspiring English sources

We previously suggested that imatinib can be effective when melanoma tumors harbor KIT mutations [ 25].

Nine cases harbor KIT exon 11 mutations, while one patient's tumor exhibited a mutation in exon 18 of PDGFRA.

Mutations in other exons are infrequent in patients who have not been treated with tyrosine kinase inhibitors (TKIs) [ 8], and 5 10 % of GISTs do not harbor KIT or PDGFRA mutation (frequently referred to as "wild-type GISTs").

Mucosal and acral melanoma arising from sites such as the palms, soles and nail beds as well as cutaneous melanoma arising from chronically sun-damaged skin are forms of the disease with different but overlapping oncogenes and biologic behavior [ 1]-[ 5] that have recently been found to harbor KIT mutations [ 6]-[ 10].

To examine whether AUY922 might enhance KIT protein degradation, GIST48, GIST882 or COS-1 cells harboring KIT mutants were treated with the protein synthesis inhibitor cycloheximide (CHX) alone or in combination with AUY922, and then the KIT protein levels were analyzed by western blotting analysis.

Two subclones were used: HMC-1.1 harboring Kit V560G but not Kit D816V and HMC-1.2 harboring both mutants (6).

The discrimination of these entities is important, as PDGFRA-rearranged tumors with eosinophilia, unlike SM harboring KIT D816V, are typically imatinib responsive.

Moreover, GISTs harboring KIT exon 9 mutations appear to be more sensitive to sunitinib than those with primary KIT exon 11 mutations (however we have observed some objective responses also in this group of patients).

By contrast, c-Kit expression, which was also analyzed, showed infrequent and weak expression and was not present in cases that revealed to harbor increased KIT copy numbers.

Approximately, 85 90% of gastrointestinal stromal tumors (GISTs) in adults harbor mutant KIT or platelet-derived growth factor receptor alpha (PDGFRA) oncoproteins 1.

Three murine models of GIST harboring germline KIT mutations have been developed using expression of KIT mutant in transgenic knock-in mice.