Sentence examples for handling pathways from inspiring English sources

BAG domain-containing proteins in cooperation with other molecular chaperones, such as CHIP and Hsp70, may contribute to the triage of misfolded proteins but, in a disease state like PD, these critical protein handling pathways may become dysregulated.

Because these different protein handling pathways in the kidney are closely related to the form and size of individual proteins, the experimental molecular weights (MWs) of proteins are therefore important for understanding the mechanisms of protein handling by the kidney.

Further evidence for this hypothesis is provided by the up-regulation of metal handling pathways and corresponding transcripts independent of iron concentration in Mo17.

These mixed results are nonetheless encouraging given that even a theoretically poor target in the calcium handling pathway of skeletal muscle produced some clinical effect when inhibited.

Strikingly, in this study the viability of melanoma cells was dose-dependently depressed in the presence of menthol, indicating that these channels underlie tumor progression via the Ca2+ handling pathway and suggesting TRPM8 channelsnnels as novel targets of drug development for malignant melanoma.

Since multiple-end pathway prediction is designed to handle branched pathways, this processing step is no longer necessary.

The code can handle exposure pathways that include: external exposure from finite or infinite atmospheric plumes; inhalation; external exposure from contaminated soil, sediments, and water; external exposure from special geometries; and internal exposures from consumption of terrestrial foods, aquatic foods, drinking water, animal products, and inadvertent intake of soil.

Evidence placing iron as a mediating factor of PD neurodegeneration is drawn from rare genetic disorders that are known to interfere with the iron-handling pathway.

These include increased synthesis of metallothionein, the prominence of the kidney in regulating ion balance and the putative role of iron-handling pathways in wider metal homeostasis.

This also leads to increased activity of PKA, resulting in modulation of downstream effectors, such as intracellular Ca2+-handling pathways, for example, phospholamban and the ryanodine receptor.

For example, macrophage activation leads to a robust down-regulation of xenobiotic-handling pathways in the liver, including many CYP and transporter proteins (Morgan, 2001; Morgan, 2009; Renton, 2001).