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These data indicated the presence of intracellular Ca2+ handling defect in cardiomyocytes from this APP/PS1 transgenic mouse model of AD.
The authors went on to show that gene-transfer of SERCA partially rescued the Ca handling defect of the DCM iPSC-CM, analogous to what has been described in various DCM animal models and humans.
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According to a systematic review on empirical studies of agile software development [1], benefits were reported in customer collaboration, work processes for handling defects, learning in pair programming, thinking ahead for management, focusing on current work for engineers, and estimation.
SCD circumvents by design the curse of dimensionality of the variable space that renders traditional ODE-based RT approaches inefficient when handling complex defect population comprised of multiple (more than two) defect species.
Herein, we present a highly controllable defect handling approach, i.e. defect creation followed by their elimination in carbon nanotubes (CNTs).
Furthermore, this defect handling technique has the potential as a general route for reversible tuning of other defect-dependent properties of sp2 carbon nanosystems.
"The objective in both the tire and the ignition cases was to avoid a costly recall in the United States, to handle costly defects through settlements in individual cases and then have those cases sealed," said Clarence Ditlow, executive director of the Center for Auto Safety and an unpaid expert witness for the plaintiffs in the ignition lawsuits.
Several machine-learning methods have been applied to handle the defect-proneness of software modules as a classification problem.
We have recently observed (unpublished data) that nBmp2NLStm mice also have cognitive deficits that are consistent with an intracellular Ca2+-handling defect in hippocampus.
As a result, if something does go wrong, a problem that might once have involved only 50,000 vehicles might today mean a recall covering more than a million.Meanwhile, there has been a significant change in attitude towards handling safety-related defects.
Reducing the work in process inventory and wasted operator's movement, labor productivity improvement, material handling improvement, zero-defects campaign's implementation, and higher flexibility in workforce planning in the face of changing demand patterns (Monden 2011) are the main benefits of the U-line as compared to a straight line.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com