Sentence examples for handling abnormality from inspiring English sources

However, this hypovolemia concept cannot explain all features of enhanced sodium retention in NS, and a primary intrarenal sodium handling abnormality was also implicated in this condition [ 2].

In summary, we have found that the intrarenal sodium handling abnormality in PAN-NS related to ANP resistance is associated with decreased abundance and altered subcellular localization of D1R in renal tubules, whereas corrected resistance to natriuretic peptides in PAN-NS resulting from inhibition of cGMP-PDE5 is accompanied by recruitment of D1R to the plasma membrane of renal tubules.

Emilin1−/− myocardium showed altered sarcomere morphology that was characterized by an increased cisternal space due to gaps between the sarcomeres and sarcoplasmic reticulum, and contracted sarcomeres with thinner Z-discs (supplementary material Fig. S2F); in addition, mitochondrial number and morphology were unaltered, consistent with a nonspecific Ca2+ handling abnormality.

Ca2+ handling abnormalities have been described in various forms of human heart failure including idiopathic dilated cardiomyopathy (IDCM) [18], [19], [20].

Calcium handling abnormalities in the atrial myocardium have been implicated in the initiation and maintenance of AF, and have been recently reviewed.

An article by Costa et al in this months edition describes a smooth mechanistic cascade from the well-accepted upstream event that mutant Htt is associated with Ca2+ handling abnormalities, through to apoptotic neuronal death.

Verapamil treatment ameliorated calcium handling abnormalities and depressed beating rhythm irregularity in HCM CMs, probably through decreasing the resting Ca2+ level and shortening Ca2+ transient duration (Supplementary material online, Figure S4E G ).

Caregaro et al showed that patients with compensated Child-A cirrhosis have sub clinical hypovolaemia and impaired natriuresis after saline loading, confirming that renal sodium handling abnormalities might precede ascites formation [ 12].

"When the wise heads of South African rugby advertised White's job a week ago, they asked for someone who could handle abnormality, intrusion and ridicule.

Several metabolic complications, accompanied by insulin deficiency or impaired insulin responsiveness and calcium handling abnormalities, are common to both types 1 and 2 diabetes [5], [6].

This indicates remodelling of the t-tubular network in the failing human heart may contribute to calcium handling abnormalities seen in heart failure and underpins many functional studies in animal models.