Calcium handling abnormalities in the atrial myocardium have been implicated in the initiation and maintenance of AF, and have been recently reviewed.
Caregaro et al showed that patients with compensated Child-A cirrhosis have sub clinical hypovolaemia and impaired natriuresis after saline loading, confirming that renal sodium handling abnormalities might precede ascites formation [ 12].
Ca2+ handling abnormalities have been described in various forms of human heart failure including idiopathic dilated cardiomyopathy (IDCM) [18], [19], [20].
An article by Costa et al in this months edition describes a smooth mechanistic cascade from the well-accepted upstream event that mutant Htt is associated with Ca2+ handling abnormalities, through to apoptotic neuronal death.
However, this hypovolemia concept cannot explain all features of enhanced sodium retention in NS, and a primary intrarenal sodium handling abnormality was also implicated in this condition [ 2].
In summary, we have found that the intrarenal sodium handling abnormality in PAN-NS related to ANP resistance is associated with decreased abundance and altered subcellular localization of D1R in renal tubules, whereas corrected resistance to natriuretic peptides in PAN-NS resulting from inhibition of cGMP-PDE5 is accompanied by recruitment of D1R to the plasma membrane of renal tubules.
"When the wise heads of South African rugby advertised White's job a week ago, they asked for someone who could handle abnormality, intrusion and ridicule.
Efficiently detecting epileptic seizure EEG signals is beneficial for handling neurological abnormalities and also for evaluating the physiological state of the brain for a broad range of applications in biomedical community.
Nevertheless, the latter may also facilitate arrhythmias through Ca2+ handling abnormalities (see below) and it is difficult to establish which mechanism prevails in a specific condition.
Several metabolic complications, accompanied by insulin deficiency or impaired insulin responsiveness and calcium handling abnormalities, are common to both types 1 and 2 diabetes [5], [6].
