Although handicapped by poor vocal projection and an unprepossessing physical appearance, Kean compensated by perfecting the details of each performance.
While these reporters are useful for imaging apoptosis in cultured cells, their in vivo application has been handicapped by poor signal to noise.
She has consistently supported women's issues around the world, children, the handicapped, the poor and the disenfranchised.
Admiring the ablest students in America is a noble practice, but in today's society, children from working-class families, from urban ghettos, from country villages, are much too often handicapped by poor schools, by broken homes, by troubled neighborhoods, to fare well in the stiff competition to enter Harvard College.
Finally, those in the profound range, comprising the smallest number of intellectually disabled, demonstrate minimal responsiveness, secondary physical handicaps, poor motor development and communication skills, and the ability to perform only highly structured work activities.
Their ability to do this is handicapped by a poor track record and a high-risk strategy.
Poor, handicapped or imprisoned Guatemalans were chosen because they were "available and powerless," said Anita L. Allen, a bioethicist at the University of Pennsylvania's law school and a panelist.
The factory's size and poor handicapped accessibility posed overwhelming challenges for the museum, which was never able to open there.
Her poor, handicapped, parents (both holders of urban Beijing hukou) already had one child, but say they continued with the second pregnancy because of a doctor's advice that aborting the foetus would endanger the mother's health.
The long-running debate over whether or not ERVs cause disease in humans has been handicapped by our poor knowledge of ERV polymorphism.
