To this aim, we decided to hamper the function of the TrkB receptor by siRNA and monitor the level of phosphorylation of Ret following RA-treatment of SH-SY5Y (Figure 4A, left panel) and LAN-5 cells (Figure 4A, right panel).
Finally, we demonstrate that mutations abolishing the membrane remodelling activity of the Pex11-Amph domain also hamper the function of full-length Pex11 in peroxisome fission in vivo.
For example, Paroxetine, a selective serotonin reuptake inhibitors often used to treat depression may hamper the function of vascular endothelial cells by impairing endothelial nitric oxide synthase, thus affecting arterial integrity leading to cardiovascular diseases [ 44].
Alcohol affects membrane and lipid-raft function both directly and indirectly by modulating the proinflammatory cascade as well as antiviral pathways and intracellular lipid storage within the parenchymal liver cells and hampering the function of nonparenchymal liver cells through both lipid-raft dependent and –independent mechanisms.
The critical passage in Draghi's comments was this: "To the extent that the size of the sovereign premia hamper the functioning of the monetary policy transmission channels, they come within our mandate".
Such construction or evolution of a new module would not significantly hamper the functioning of the old modules, and are thus favorable both for engineering purposes and for evolution, which could be facilitated [31] by this module-level modification.
Finally, as the private sector appears to be an important provider of reproductive health services in the three countries studied, care should be taken to prevent the implementation of policies or regulations that significantly burden or hamper the functioning of the private sector lest national-level reproductive health indicators suffer as a result.
Data accumulating over the last few years led to the notion that Bcl-xL deamidation induces a profound structural modification, which, in turn, hampers the antiapoptotic function of this protein.
In addition, ApoE hampers the proinflammatory functions of inflammatory cells.
Such features may not only bring ZnO NPs to be closer to the membrane of bacteria to hamper the normal function of bacteria [21] but also increase the local zinc concentration to inhibit the growth of bacteria [22].
