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The pathogenic mechanisms of LPHS are poorly understood which hampers the application of effective treatment regimes.
However, the conformational plasticity of these molecules hampers the application of traditional structural approaches, and new tools and concepts are being developed to address the challenges they pose.
The operating behavior is complex and not straight-forward to predict, which hampers the application of classical methods for the design of such a reactor.
However, the binding domain of RAGE is natively unfolded in physiological conditions, which severely hampers the application of classic methods of protein structure analysis to the design of an antagonist.
These contradictory requirements are reflected by the design principles of existing software solutions: programs for routine application are barely extensible or modifiable by the user and the complexity of highly flexible data processing tools for research purposes hampers the application of new methods to larger data volumes.
However, it suffers from fast capacity fading, which greatly hampers the application of Si anode materials.
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Low thermostability often hampers the applications of xylanases in industrial processes operated at high temperature, such as degradation of biomass or pulp bleaching.
Both these aspects may hamper the application of reset control in industrial settings.
The postruminal modification of the OBCFA profile might hamper the application of OBCFA as diagnostic tools of rumen function.
However, due to the nonlinear nature of orbital dynamics, problems such as low precision and intensive computation have greatly hampered the application of these methods.
All these features should help to lower the challenges and hurdles hampering the application of data-assimilation techniques in operational hydrological modeling.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com