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We reasoned that one of the difficulties hampering the understanding of this process comes from a shortage of methods to evaluate the functional cell polarity, which is observable as intracellular events.
The determinants of this specificity are still only partly understood and as a consequence it is difficult to predict kinase substrate preferences from the primary structure, hampering the understanding of kinase function in physiology and prompting the development of technologies that allow easy assessment of kinase substrate consensus sequences.
To date, only a few target genes have been identified in the brain [ 13], severely hampering the understanding of defects caused by developmental hypothyroidism.
The simple node-and-edge network representation is useful, but limited, hampering the understanding of the mechanistic details of signaling pathways.
Despite this central importance of noncoding variants, the lack of experimentally validated regulatory mechanisms is hampering the understanding of the regulatory mechanisms underlying observed genotype phenotype associations.
Nevertheless, the expression of PD-1 and its ligands PD-L1 and PD-L2 during TB remains incompletely defined, thus hampering the understanding of how PD-L1/PD-1 may regulate the immune response to Mtb.
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Nevertheless, the lack of well characterized foreland system depocenters and the paucity of precise geochronological data have hampered the understanding of its basinal evolution.
Research on self- and family management of chronic conditions has advanced over the past 6 years, but the use of simple frameworks has hampered the understanding of the complexities involved.
Meanwhile, it is also a barrier for genetic manipulation such as conjugation [8] and transformation [9], which hampers the understanding and exploitation of many important bacteria through genetic manipulation.
This lack of a standardized approach hampers the understanding, research and clinical care of GDM (3).
Such a combination hampers the understanding of which intervention is (most) effective [ 35].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com