Further, the downstream assembly process might purge variation within a polymorphic sample, hampering the detection of SNPs and indels (Miller et al. 2010).
Moreover non-identifiable parameters are not explicitly considered hampering the convergence of such sampling techniques and yielding results that are questionable and difficult to interpret [ 14].
Firstly, as discussed above, we could not obtain peripheral and cord blood, amniotic fluid and urine samples from every patient, hampering the comparability of pro-protein levels among different samples.
When a small amount of noise, such as the variability due to sampling imprecision hampering the perfect localization of a local maximum or minimum, is included in a birhythmic system, the bisecting lines appear as two narrow bundles of lines rather than two single lines, e.g. the birhythmic Verhulst system in Figure 8, right.
Measurements of mupirocin effects on the established (18 h-formed) biofilms were then performed, but the registered antibiofilm activity did not exceed 50% for both M and LM samples, thus hampering the estimations of their potencies (as expressed by IC50 values).
Thirdly, the limited sample size is hampering the expression study.
Investigations of B. pseudomallei in Laos have highlighted the challenges of detecting the pathogen in different environmental samples (9, 12), hampering the development of a detailed risk map (9).
Nevertheless, at least some of the sequencing projects in the Florideophyceae dbEST are also based on non-axenic field samples [ 51, 52], hampering the achievement of a more accurate estimate.
However the lack of genuine comparators hampered the number of samples that could be tested, only 35.2%.
Given that cell aging processes are considered to be related to life expectancy, it is possible that the advanced age of our sample hampered the detection of a relationship between telomere length and markers of mental well-being.
