Immunosuppression associated with ovarian cancer (OC) and resultant peritoneal carcinomatosis (PC) hampers the efficacy of many promising treatment options, including immunotherapies.
Existence of low frequency segments, such as ramp-type trends, in a pattern hampers the efficacy of the harmonizing step.
In addition to their clinical symptoms, patients also show an underperformance in neurocognitive functioning that may hamper the efficacy of cognitive behavioral therapy (CBT) [2].
The failure to effectively address the discriminatory impact of PCVE strategies on women not only hampers the efficacy of PCVE efforts but also impedes state party implementation of the Convention on the Elimination of All Forms of Discrimination against Women (CEDAW), which requires elimination of discriminatory laws, policies, and programming.
The decrease in tumor proliferation upon FGFR inhibition could hamper the efficacy of the radiation.
Importantly, some HBV genotypes may hamper the efficacy of NUCs in HBV-mono-infected patients [ 21].
Antioxidants may hamper the efficacy of chemotherapy by scavenging reactive oxygen species and, on the other hand, alleviate unwanted chemotherapy-induced toxicity, thus allowing for increased chemotherapy doses.
Because cannabinoid receptors are known to desensitise upon prolonged occupancy (Howlett et al, 2002), it is conceivable that this may hamper the efficacy of long-term treatments.
This fact, although favorable in normal conditions, may hamper the efficacy of the treatment of immunological disorders because the pharmacological manipulation of the activity of a single system alters the activity of other systems, thus neutralizing the therapeutic effect achieved.
The fight to reduce mosquito densities has been partially successful in some places, but the rapid development of resistance to chemicals and many other operative hurdles hamper the efficacy of these programs [ 20].
