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This approach is hampered by the development of resistance to commercial acaricides among cattle tick populations.
All treatment strategies, including multidrug regimens, however, are eventually hampered by the development of drug resistance.
Currently there are no prospects for a vaccine, and acaricide or antibiotic control is hampered by the development of chemoresistance.
Lamivudine is widely used for prophylaxis; however, its efficacy is hampered by the development of viral mutations that result in drug resistance [ 39].
However, the initial chemotherapeutic efficacy is often hampered by the development by tumor cells of mechanisms of escape from the chemotherapeutic control, allowing residual cancer (stem) cells to growth, invade and metastasize.
Even in these early years it was clear that nitrate therapy was hampered by the development of nitrate tolerance, although the mechanisms for this were not understood and indeed are still being elucidated today [ 8].
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Unfortunately, the efficacy of chemotherapy is hampered by the eventual development of MDR.
Unfortunately, the efficacy of these agents is hampered by the eventual development of multidrug resistance (MDR).
The use of sulfur-fluoride bonds represents a growing trend in drug development, hampered by the discovery of the substantial stability of several moieties containing such bond.
Despite much discussion and many theoretical studies, getting relevant quantum technology into space has been hampered by the cost of traditional space development.
The main obstacle represents identification of an appropriate therapeutic target, which has been largely hampered by the time and money-consuming development of new drugs, especially for neglected diseases.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com