Unfortunately, the majority of chemotherapy, which has a substantial hydrophobic component, is usually hampered by problems such as lack of tumor selectivity, poor water solubility, uncontrollable pharmacokinetic processes, and the possible incurrence of severe side effects [1 3].
It has been hampered by problems such as the number of new terms being created on a regular basis, the lack of standardization of technical terms between authors, and often by the fact that technical terms, such as gene names, often occur with other terminologies [1].
Nevertheless, the SIGAR report said, those forces continue to be hampered by internal problems — such as poor leadership and corruption — as well as by an agile and determined foe that is making it difficult for them to control territory.
According to Selig Harrison, director of the Center for International Policy's Asia program, "Unlike Eastern Europe, where TV, short-wave radios and cassettes leapfrogged national boundaries, North Korea has been tightly insulated from outside influences". North Korean development is hampered by major problems, such as the perceived need to support a huge army, and by widespread poverty.
In practical terms, participants said they were hampered by logistic problems, such as arranging and waiting for test results and other specialists involved, and a shortage of facilities.
Several studies have described GPs' CAM views [ 14] and practices [ 15]; however, most of them have been hampered by methodological problems such as small sample size, convenience sampling, or unsatisfactory response rates [ 16].
The majority of older clinical studies focusing on diabetes mellitus and risk of osteoporosis are hampered by methodological problems, such as: relatively small sample sizes; heterogeneous study populations; and the use of different techniques and measurement sites for BMD.
In AMD however, healing is hampered leading to problems such as incomplete RPE coverage and the consequent death of overlying photoreceptors.
Others, like Maryland and Oregon, are hampered by problems like those imperiling the federally run site.
Although they have their advantages, respectively, each of the above is hampered by one or more problems, such as complicated preparation process, high cost, and low stability of the formulation.
At that same time, fire fighting was hampered by such problems as a lack of equipment and low water pressure for hoses.
