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Also, the dearth of murine models that mimic cccDNA formation has hampered analysis in vivo.
Important classes of macromolecules, such as membrane proteins (including many receptors) and macromolecular complexes, are difficult to obtain in quantity and to crystallise, which has hampered analysis by MX.
Lack of a suitable animal model has so far hampered analysis of metastatic progression.
The difficulties in producing and purifying JH2 domains have hampered analysis of their effect on JAK2 enzymology, function and signaling.
The lack of a general marker for intestinal stem cells across species has hampered analysis of stem cell number in different species and their adaptive changes upon intestinal lesions or during development of cancer.
Firstly, there was no information on the exact part numbers of the components used and some surgeons kept on using obsolete generic names, which hampered analysis of implants.
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That hampers analysis, reuse and maintenance in general.
Poor serum quality can hamper analysis and complicate result interpretation.
One factor hampering analysis can arise from low-coverage genomes [ 21, 22] which makes mapping and identification of miRNAs difficult.
In contrast, plasma DNA is easily obtained; however, tumor DNA fragments are diluted with various amounts of DNA from normal cells, which may hamper analysis.
The variable sequences and numbers of repeats in PARCEL-containing ORFs hampers analysis of HGT using orthology to compare their phylogenetic congruence with the organisms harboring them [ 64].
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