This study attempted to reverse tamoxifen (TAM -resistance in breasTAM -resistanceencing a mitochondrial enzyme, manganese superoxide dismutase (MnSOD), which dismutates TAM-induced reactive oxygen species (ROS) (i.e., superoxide) to less harmful hydrogen peroxide and hampers therapeutic effects.
In addition, most of current anticancer agents usually have short circulation half life and poor aqueous solubility, which hampers therapeutic efficacy of chemotherapy [4, 5].
In addition, most of current anticancer agents usually have short half-life in the blood circulation and poor aqueous solubility, which hampers therapeutic efficacy of chemotherapy [7, 8].
However, in contrast to infectious disease antigens, many allergens have been reported to be weak immunogens [4] [7], a property hampering therapeutic success.
However, side effects have hampered therapeutic usefulness.
In recent years there has been an emerging need for a new or expanded definition of ARDS as the definition includes a heterogeneous population, thus creating noise and hampering therapeutic advances in the field.
However, the lack of suitable pre-clinical NEPC models has limited investigations into the molecular underpinnings of NEPC, therefore hampering therapeutic development of novel agents to treat this deadly disease.
Diffusion limitations on the penetration of nanocarriers in solid tumors hamper their therapeutic use when labeled with α-particle emitters.
Such dysfunction makes behavioral change difficult for heavy drinkers and thus may hamper successful therapeutic intervention.
However, it has been reported that DNA re-methylation and gene re-silencing could occur after removal of demethylation treatment and this may significantly hamper the therapeutic value of DNA methylation inhibitors.
