However, most hiPSC-derived CMs morphologically and functionally resemble immature rather than adult CMs, which could hamper their application.
However, adverse events in which vector integration activates proto-oncogenes, leading to clonal expansion and leukemogenesis hamper their application.
Adverse events in otherwise successful clinical trials caused by proto-oncogene activation due to vector integration hamper their application.
However, in some instances it is claimed that the low density and low mechanical strength of the macroscopic particles hamper their application.
However, most NIR dyes usually have one or more charge in their structures, which may cause low cell membrane permeability and hamper their application in cell imaging.
However, adverse events in gene therapeutic trials, caused by activation of proto-oncogenes due to murine leukemia virus (MLV -derived vector integration, haMLV -derivedpplication.
Our previous experiments indicated that bone marrow mesenchymal stem cells of rhesus monkey (RhBMSCs) have a low proliferative ability with a finite life span, which will hamper their application in biomedical research.
The ability of hPSCs to differentiate is a crux of many potential applications of these cells, and changes in differentiation ability would not only affect efficient production of differentiated cell types for cell therapy, but could also hamper their application in disease modeling and drug discovery (Goldring et al., 2011).
aegPNAs bind corresponding RNA sequences with high affinity and specificity, however, unfavourable properties like their low solubility hamper their application in vivo.
