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In addition, the number of patients included in this substudy was low, and this may hamper the validity of our results.
This may decrease the ability of the study to generalize the findings to other regions, but should however not hamper the validity of the data.
Moran's I index was computed on the residuals of each ANOVA to test for any possible spatial autocorrelation that could hamper the validity of our inferences.
15 Such changes clearly hamper the validity of trials, however it is not possible to trace and document if the trials are not registered correctly.
Drugs prescribed in-hospital are not registered on an individual level, which may hamper the validity of register-based studies on drugs potentially administered in-hospital.
Although the number of patients in the present study is limited, this does not necessarily hamper the validity of this study as a higher number of patients would only increase precision.
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High percentages of missing values on specific items might even indicate that an item is not relevant for the study population, perhaps pointing to ambiguous formulations and hampering the validity of the instruments [ 17, 49].
Population level studies for assessment of magnitude of HIV infection suffer from potential biases, which are likely to hamper the validity and reliability of results [ 20].
This might hamper the external validity of our study.
This selection strategy may hamper the external validity of the study.
First, we encountered an unexpectedly low response rate during the telephone-interview stage, with one-third not being reachable after multiple attempts, and another one-third refusing the telephone interviews, which hampers the external validity of the current study.
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