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The phrase "hamper the efficacy" is grammatically correct and can be used in written English.
It means to hinder or impede the effectiveness or success of something. For example: The lack of funding for the project will hamper its efficacy in achieving its goals.
Exact(9)
In addition to their clinical symptoms, patients also show an underperformance in neurocognitive functioning that may hamper the efficacy of cognitive behavioral therapy (CBT) [2].
Importantly, some HBV genotypes may hamper the efficacy of NUCs in HBV-mono-infected patients [ 21].
The decrease in tumor proliferation upon FGFR inhibition could hamper the efficacy of the radiation.
Antioxidants may hamper the efficacy of chemotherapy by scavenging reactive oxygen species and, on the other hand, alleviate unwanted chemotherapy-induced toxicity, thus allowing for increased chemotherapy doses.
Because cannabinoid receptors are known to desensitise upon prolonged occupancy (Howlett et al, 2002), it is conceivable that this may hamper the efficacy of long-term treatments.
The fight to reduce mosquito densities has been partially successful in some places, but the rapid development of resistance to chemicals and many other operative hurdles hamper the efficacy of these programs [ 20].
Similar(50)
Existence of low frequency segments, such as ramp-type trends, in a pattern hampers the efficacy of the harmonizing step.
1, 3– 6 Another major problem hampering the efficacy of many anticancer drugs is the acquisition of drug resistance.
The toxicity observed in treating these patients is still relevant and in someway might hamper the clinical efficacy.
In this regard, it is not surprising that the acquired more potent metastatic ability of MDR cells caused by traditional cytotoxic drugs usage may heavily hamper the chemotherapeutic efficacy, like MDR does.
However, the low retention and poor survival of engrafted cells hampered the therapeutic efficacy of engrafted MSCs.
More suggestions(16)
hamper the adequacy
disrupt the efficacy
impede the efficacy
inhibit the efficacy
hamper the validity
hamper the performance
hamper the therapeutic
hamper the effect
hamper the efficiency
hamper the trial
inhibited the efficacy
hamper the efficient
impair the efficacy
hamper the effective
impedes the efficacy
hinders the efficacy
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com