Earlier GWA studies of personality (De Moor et al. 2010; Service et al. 2012; Shifman et al. 2008; Terracciano et al. 2010; van den Oord et al. 2008) focused on single inventories, hence hampering sample size, and few, if any, genome-wide significant loci were detected.
Although duplicate-portion collection provides precise measurement, it is disadvantaged by its heavy burden on sample donors, which hampers sampling of large populations and accordingly limits case numbers and analysis of specific cancer sites.
However, when 2 g acid silica gel at 30% sulfuric acid was used, the column was plugged hampering the sample elution, so 4 g silica gel at 15% sulfuric acid was selected as optimal value.
However, the power of primary aim was not hampered by sample size because of the large effect size, i.e. the diagnostic accuracy difference of EBUS-TBNA and PET.
Although hampered by sample numbers, genome-wide mapping and next-generation sequencing might be applied toward this goal.
The ability to create more detailed groupings of maternal origin, ideally at the country level, was hampered by sample size considerations and consistency across participating countries.
In the same vein, the ability to create more detailed groupings of maternal origin, ideally at country level, was hampered by sample size considerations and consistency across participating countries.
In addition, molecular diagnostics based on analysis of biopsied or surgically resected tumor tissue is hampered by sampling error.
During volcanic unrest (including phreatic eruptions), perturbations of the water surface and strong upward air currents caused by enhanced lake water evaporation can further hamper efforts to sample water near the lake surface.
However, most studies are hampered by small sample sizes.
