The noise from the latter factors may significantly influence the intra-individual variation in drug disposition and thus hamper outcome prediction by genetic polymorphisms.
This enables researchers to produce a detailed account of sociocultural, political and economic contextual factors that support or hamper desired outcomes.
Healthcare implications of this study include the notion that psychological distress might hamper the outcomes of intensive lifestyle and other treatment interventions targeted at high-risk groups (2, 3).
54, 55 In contrast, low doses of idebenone failed to render neurological benefits in similar clinical settings, 56 suggesting a critical issue regarding the appropriate dose, perhaps hampering positive outcomes in other studies.
In this review, we go over major clinical trials conducted in SLE by analyzing any critical aspects related to study design, predefined endpoints and biological activity of novel compounds that may have hampered study outcome, despite the great effort of providing less toxic drugs within a targeted, pathogenic-based approach.
Screw removal, when intact after 4 6 months, might be justified if the positioning screw gives rise to physical complaints, e.g., when dorsiflexion is hampered or outcome appears to be affected.
Risk factors accounting for hampered psychological outcome could be diverse (severity of illness, being removed from one's child, having been witness to the accident, mental health, family functioning, social support, coping strategies and lack of information from the medical team) [ 17, 26, 29, 31].
The many inflammatory and endothelial activation biomarkers in the literature hamper collation of outcomes.
Postponing LGE during pregnancy to the second trimester or puerperium however, is unnecessary and in most cases unwanted because of the therapeutic delay which might hamper the pregnancy outcomes more than the LGE itself.
However, their specific antigen profile may hamper the clinical outcome of immunotherapeutic strategies for these patients.
