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Therefore, Kidins220 PDZ-L cleavage will rapidly uncouple this effector from these and other yet unknown downstream signaling pathways and hamper functions mediated by this motif.
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But since globular proteins are, in general, only marginally stable [7], such replacements could be at odds with productive protein folding and also hamper function independently.
Hence, the removal of such can potentially hamper function inference.
Another reason for this hampered function is the formation of mispaired TCR dimers.
Constitutively expressed TCR molecules were reduced on the cell surface depending on the induced TCR expression leading to strongly hampered function.
They cover a range of scenarios of how damage hampers functioning, and of how damage is passed on to the progeny upon division.
These findings have been related to the weak central theory which predicts that processing information globally may hamper perceptual functions in autism [23].
The critical passage in Draghi's comments was this: "To the extent that the size of the sovereign premia hamper the functioning of the monetary policy transmission channels, they come within our mandate".
Such construction or evolution of a new module would not significantly hamper the functioning of the old modules, and are thus favorable both for engineering purposes and for evolution, which could be facilitated [31] by this module-level modification.
To this aim, we decided to hamper the function of the TrkB receptor by siRNA and monitor the level of phosphorylation of Ret following RA-treatment of SH-SY5Y (Figure 4A, left panel) and LAN-5 cells (Figure 4A, right panel).
As already noted, acute hyperglycemia within minutes can hamper endothelial function and may even induce paradoxical vasoconstriction.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com