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In a series of 102 severely traumatized patients, the infusion of crystalloid solutions during the first 24 hours was associated with subsequent aggravation of pulmonary dysfunction [13].
Takahashi et al. assumed that obesity provoked lordosis and led to a narrowing of the spinal canal with subsequent aggravation and functional loss [ 28].
In a series of 102 severely traumatized patients, the infusion of crystalloid solutions during the first 24 hours was associated with subsequent aggravation of pulmonary dysfunction [ 13].
The malfunction of the ERAD itself is thought to contribute to the development of ER stress and subsequent aggravation of several neurodegenerative diseases [ 52].
Therefore it is likely that HVt ventilation after acid instillation, with a tidal volume distributed over a smaller aerated lung volume, led to repeated alveolar overdistension and subsequent aggravation of lung injury.
When that was halted, subsequent studies in the 2000s suggested the major decline had been arrested.
Patients were recommended to freely move and use the symptomatic upper limb within the limits of immediate and subsequent pain aggravation.
Long-term treatment of RDEB mice efficiently reduced TGF-β signaling in chronically injured forepaws and halted fibrosis and subsequent fusion of the digits.
Talking of understaffing, this is also tough on YOI night staff who will lose their "electronic babysitter" and have to deal with the subsequent anger, restlessness and aggravation.
In many patients however, DMARD therapy alone is insufficient to halt disease progression and subsequent treatment with more targeted therapies is now commonplace.
And everything will grind to a halt pretty quickly if the subsequent action doesn't yield real results.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com