Sentence examples for hallmarks of malignancy from inspiring English sources

On the contrary, the enhanced synthesis, trafficking and extracellular release of lysosomal proteases (cathepsins), are important hallmarks of malignancy and associate with the invasive and metastatic capacity of cancer cells [3], [4].

While the molecular mechanisms underlying the process of reprogramming remain obscure, recent reports indicate that classical hallmarks of malignancy such as inactivation of the p53 pathway [8] [10] or silencing of the ink4/arf locus [11] leading to immortalization [12] are shared between somatic cell reprogramming and cell transformation.

Specifically, cancer cells acquire the hallmarks of malignancy as they accumulate multiple, rate-limiting mutations.

The incontrovertible hallmarks of malignancy are invasion of cells though a basement membrane and/or metastasis.

HIF-1α activation in human cancers also promotes several hallmarks of malignancy.

Invasive growth of tumors is one of the most important hallmarks of malignancy [ 17, 18].

Invasion, the hallmark of malignancy, consists in the translocation of tumour cells from the initial neoplastic focus into neighbouring host tissues, and also allows tumour cells to penetrate vessel endothelium and enter the circulation to form distant metastasis.

Today, tumor metastasis still represents the hallmark of malignancy in cancer.

These data are relevant since, at least in some cancer settings, down-regulation of α5β1 integrin is a hallmark of malignancy [39].

This finding indicates that CXCR4 can, at least in part, compensate for serum depletion, and increases survival in stress conditions, a hallmark of malignancy.

The unlimited proliferation potential of cancer cells is a major hallmark of malignancy, however the use of standard tissue culture protocols often restricts cell proliferation, as observed with primary cell lines [1], [2], [3], [4].