Sentence examples for hallmarks of aging from inspiring English sources

López-Otín et al. defined nine "hallmarks of aging" that are causally linked with the aging process and together contribute to the aging phenotype, i.e. genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, altered intercellular communication and stem cell exhaustion [ 4].

Hallmarks of aging include impaired default network modulation and declining medial temporal lobe (MTL) function.

Memory dysfunction is one of the main cognitive hallmarks of aging.

Collapse of proteostasis and accumulation of damaged macromolecules have been recognized as hallmarks of aging and age-related diseases.

The epigenetic changes are one of the hallmarks of aging, including alterations in transcription factor binding, histone marks, DNA methylation, and nucleosome positioning [18].

We recently proposed that the essential nature of the hallmarks of aging for the organism makes it very likely that one or the other pathway will be dysregulated in any chronic lung disease [12].

The key components of the musculoskeletal system and their functions are introduced together with a general overview of the molecular hallmarks of ageing.

Loss of proteostasis has been proposed as a major hallmark of aging [11].

Mitochondrial dysfunction has been proposed as another hallmark of aging [11].

Mitochondrial dysfunction, a hallmark of aging, is known to result in altered bioenergetics and excessive production of reactive oxygen species (ROS).

The focus of the first part of the article is on recent studies using cell-derived decellularized ECM, which strongly suggest that age-related changes in the ECM induce cellular senescence, a well-recognized hallmark of aging.