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On the other hand, the complex symptoms of AD and their partial correlation with pathological hallmarks indicate that understanding the pathogenesis of AD may require investigations of abnormalities at multiple levels; this would enhance our awareness that various compensatory mechanisms are at work in maintaining brain functions [9].
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Noteworthy is that the analyses performed in high- and low-glucose cultures indicate that reduction of glucose availability induces, especially in transformed cells, a significant increase in the expression of several unfolded protein response (UPR) hallmark genes.
This indicates that loss of apical-basal polarity is indeed a hallmark of the generation of rodent BPs.
A functional pathway analysis then revealed that the signature genes had interactions with well established cancer hallmarks, indicating the important roles of the signature genes in tumor initiation and progression.
The reversibility of these hallmark changes indicates that the involuted state induced in the thymus by ageing is not locked, for instance by epigenetic or other mechanisms that result in permanent loss of key functions, even once fully established.
While the molecular mechanisms underlying the process of reprogramming remain obscure, recent reports indicate that classical hallmarks of malignancy such as inactivation of the p53 pathway [8] [10] or silencing of the ink4/arf locus [11] leading to immortalization [12] are shared between somatic cell reprogramming and cell transformation.
Failure to identify the hallmarks of infection does not indicate that infection can be ruled out.
Our results indicate that the histopathology hallmark of FHC, namely the sarcomeric disarray, may be directly linked to molecular level variability of the R403Q myosin molecule while complexed with actin.
Our findings of several replicated mRNAs prognostic of recurrence indicate that there are consistent hallmarks of refractory disease that may have clinical utility.
Our results indicate that fatty liver, a hallmark of obesity-associated metabolic syndrome, is enhanced by the CB2 receptor agonist JWH-133 and blunted by Cnr2 knock-out.
Jawbone's updates contends that Fitbit's latest products contain "hallmarks of Jawbone's proprietary technology, and thereby indicate that Jawbone's trade secrets have already been put to use by [Fitbit]".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com