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The Chinese SVCV has some unique molecular hallmarks compared with its European and American counterparts.
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In addition, it should be noted that our results apply to the pandemic scenario where a shift in the age distribution toward greater morbidity and mortality in younger age groups is a recognized hallmark compared to seasonal influenza [ 14].
Larvae reared on a high-sugar diet were hyperglycemic, insulin resistant and accumulated fat – hallmarks of T2D – compared with those reared on control diets.
The pronounced, preclinical involvement of the lymphoid tissues, which appears to be a hallmark of vCJD compared to sporadic CJD (sCJD) infection, conceivably enhances the risk of human-to-human transmission [8] [11].
Dysregulated, larger and loosely arranged ECM is a hallmark of leiomyomas compared to surrounding myometrium.
CD18/HPAF/Scr cells also showed reduced DNA fragmentation, a hallmark of apoptosis, compared with CD18/HPAF/siMUC4 cells.
These experiments showed that alterations in M-band composition are a hallmark of DCM compared to HCM models or controls.
The synergistic effect was confirmed through the enhancement of apoptosis when the combination induced momentous increase in the internucleosomal cleavage of DNA, the biochemical hallmark of apoptosis, compared with that induced by 5-FU and curcumin alone.
This allowed us to show that ME gene mutations are more prevalent in pathways compared with hallmarks, and conversely, that CO gene mutations are relatively important to enable hallmark characteristics.
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This is supported by GenMAPP analysis identifying two of these pathways to be most differently regulated between metastasizing and non-metastasizing tumors (CELL_CYCLE_KEGG and G1_TO_S_CELL_REACTOME). Up-regulation of cell cycle and proliferation is a hallmark of cancer cells compared to normal cells.
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