The mTOR signaling pathway is critical to cell growth, proliferation, and survival and rapamycin inhibits these hallmark processes of cancer.
Cortical development and white matter myelination are hallmark processes of infant and child neurodevelopment, and play a central role in the evolution of cognitive and behavioral functioning.
β-Hydroxypyruvate is an example of a strong association of a newly reported metabolite with hallmark processes in diabetes.
SIRT3 regulates most of the cancer hallmark processes, suggesting SIRT3 can be considered as a novel potential therapeutic target for the treatment of cancer.
Reduced neurite length and branching points were observed for Mbd5 +/GT neurons, suggesting an important role for MBD5 in hallmark processes of neuronal differentiation such as neurite outgrowth and maturation.
10, 17– 23 From the earlier description, it is evident that the three kinases are involved in the hallmark processes, ie, smooth muscle cell proliferation and exaggerated vasoconstriction, which are associated with HAPE.
As a result, genes in the module significantly involved in many biological pathways such as "NOD-like receptor signaling pathway", "MAPK signaling pathway", "apoptosis," and "tight junction" that have been known as hallmark processes of tumor).
MRC5 fibroblasts also underwent myofibroblast transdifferentiation more readily in response to TGF- β than control cells, suggesting that the functional impact of stromal miR-21 on the hallmark processes of tumour progression may be linked to the myofibroblast phenotype.
Keywords for cancer hallmark processes included those used by Kleinstreuer et al. (2013); a comprehensive list of keywords is included in Supplemental Materials, "Keywords for searches of assays in Tox21 and ToxCast".
