hallmark of disease

USAGE SUMMARY

The phrase 'hallmark of disease' is correct and usable in written English.
You can use it to refer to a characteristic symptom or sign that is typical of a particular disease. For example, "Fatigue is a hallmark of many chronic diseases."

✓ Grammatically correct

Science

Science & Research

Academia

News & Media

Encyclopedias

Human-verified examples from authoritative sources

Exact Expressions

14 human-written examples

This, in turn, appears to trigger the fibrillization of the inclusion bodies that are a hallmark of disease.

Nature

Accurate and reliable estimates of kidney and cyst volume, the hallmark of disease progression in ADPKD are now available.

Kidney International

Moreover, in the majority of those with ALS and FTD, the pathologic hallmark of disease is the cytoplasmic deposition of the nuclear RNA binding protein TDP4317, implying a common mechanism underlying these clinically-overlapping neurodegenerative disorders.

Nature

With the aim of identifying a worsening factor in MOH, rather than the detection of a specific risk factor for the development of the disease, we investigated whether the presence of a functional BDNF polymorphism might determine clinical differences within a group of 90 MOH patients, particularly in monthly drug consumption, that is the hallmark of disease.

The Journal of Headache and Pain

Aim of this study is to confirm our hypothesis that allele A of the examined BDNF polymorphism interfere with MOH, seeking for clinical and psychiatric differences between the two groups, mainly in the monthly drug consumption, that is both the clinical hallmark of disease, and the feature closest to abuse disorder.

The Journal of Headache and Pain

Finally, reduced levels of Bdnf promoter transcripts are a hallmark of disease progression in Huntington's disease (Zuccato et al., 2001).

Brain

Human-verified similar examples from authoritative sources

Similar Expressions

46 human-written examples

Altered glycolysis is a hallmark of diseases including diabetes and cancer.

Princeton University

CRISPR-Gold was also able to reduce tissue fibrosis – the hallmark of diseases where muscles do not function properly – and enhanced strength and agility in mice with Duchenne muscular dystrophy.

University of California, Berkeley

Importantly, chronic NET formation, or NETosis, is a hallmark of diseases including rheumatoid arthritis, lupus, and numerous cancers.

Biochemistry

Thus, the normal condition of an organism must be understood in order to recognize the hallmarks of disease.

Britannica

The idea that the hallmarks of disease could be detected through computational analysis has been alluring to engineers.

The Washington Post

Expert writing Tips

Best practice

Use "hallmark of disease" to introduce a particularly notable or definitive characteristic, rather than a common or general symptom.

Common error

Avoid using "hallmark of disease" for every symptom or sign. Reserve it for the most distinctive and critical features that define the disease.

Linguistic Context

The phrase "hallmark of disease" functions as a noun phrase that identifies a key, defining characteristic of a particular disease. Ludwig AI indicates its grammatical correctness. Examples from Ludwig show it used to describe key features like 'amyloid plaques' in Alzheimer's.

Expression frequency: Common

Frequent in

Science

60%

Science & Research

20%

Academia

13%

Less common in

News & Media

4%

Encyclopedias

3%

Formal & Business

0%

Ludwig's WRAP-UP

The phrase "hallmark of disease" is a common and grammatically correct expression used to denote a key, defining characteristic of a specific disease. As Ludwig AI confirms, it's frequently used in scientific, academic, and medical contexts to highlight significant signs or symptoms. Examples from Ludwig illustrate its use in describing conditions like Alzheimer's, Huntington's, and autoimmune disorders. The most frequent contexts are science, science and research, and academia. While alternatives like "characteristic of disease" or "defining feature of disease" exist, "hallmark of disease" remains a strong and recognizable term for emphasizing a disease's most telling features. Remember to reserve it for the most distinctive and critical features of a disease, not just any symptom.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

characteristic of disease

Replaces "hallmark" with a more general term for a typical feature.

defining feature of disease

Highlights the attribute that most clearly identifies the disease.

key indicator of disease

Focuses on the phrase as a sign that points to the disease.

distinguishing trait of disease

Emphasizes the unique quality that sets the disease apart.

typical symptom of disease

Specifies that the hallmark is a symptom, making it more clinically oriented.

classic sign of disease

Uses "classic sign" instead of "hallmark" to convey a well-recognized indicator.

primary marker of disease

Focuses on the phrase as a biological or diagnostic marker.

major characteristic of disease

Uses "major characteristic" for emphasis, implying significance.

essential attribute of disease

Highlights the fundamental nature of the attribute in defining the disease.

pathognomonic sign of disease

Indicates a highly specific sign that is almost definitive for the disease.

FAQs

What does "hallmark of disease" mean?

The term "hallmark of disease" refers to a key characteristic, sign, or symptom that is particularly indicative or diagnostic of a specific disease. It's a defining feature that helps in identifying and understanding the disease.

How can I use "hallmark of disease" in a sentence?

You can use "hallmark of disease" to highlight a specific feature of a medical condition, such as: "Amyloid plaques are a hallmark of Alzheimer's disease" or "Chronic inflammation is often a hallmark of autoimmune diseases".

What are some alternatives to "hallmark of disease"?

Alternatives to "hallmark of disease" include "characteristic of disease", "defining feature of disease", or "key indicator of disease". The best choice depends on the specific context.

What's the difference between "symptom of disease" and "hallmark of disease"?

While a "symptom of disease" is a general sign of illness, the "hallmark of disease" refers to a particularly distinctive or definitive characteristic. Not every symptom is a hallmark, but every hallmark is a significant symptom or sign.