The phrase "hallmark changes" is correct and can be used in written English. It refers to significant or defining changes that are characteristic or indicative of something. Example: The company's new CEO implemented hallmark changes in the company's policies and procedures, leading to increased productivity and profitability.
Basal deposits and Bruch membrane thickening are hallmark changes of aging.
It is also assumed that the "hallmark changes" occur along a certain timeline, but that some of the sub-processes discussed before are concurrent.
Apoptosis is a form of a programmed cell death where cell undergo specific hallmark changes during progression towards death [ 32].
Many patients with both PDD and DLB have hallmark changes in the brain, including plaques and tangles that are associated with AD.
Some of the hallmark changes that facilitate epithelial cell dissemination and migration during cancer progression are downregulation of both cadherin-based cell cell and cell matrix adhesions.
ErBb2 mouse models show remarkable morphological resemblance to some forms of human breast cancer and accurately recapitulate the hallmark changes associated with the early stages of human breast cancer [ 27].
The new role of stemness as a hallmark change of cancer cells is also supported by the observation that histologically poorly differentiated tumors show transcriptional profiles on which there is an overexpression of genes normally enriched in embryonic stem cells.
The APOPercentage assay (http://www.biocolor.co.uk/) captures apoptotic cells representing a hallmark change on the surface of plasma membranes i.e. phosphatidylserine (PS) externalization.
And within those types, they found hallmark genetic changes that are driving many cancers.
Both, granulomas and multinucleated giant cells, are the hallmark histopathological changes in sarcoidosis.
Cancer cells undergo metabolic reprogramming as one of their hallmark behavioural changes during the tumorigenic process (7).
