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However, in the AD brain, vimentin has been found within neurofibrillary tangles, a pathological hallmark associated with the disease [ 78, 79].
Accumulation of aggregated forms of αSyn (α-synuclein) into Lewy bodies is a known hallmark associated with neuronal cell death in Parkinson's disease.
In the past years, the introduction of magnetic resonance spectroscopy (MRS) for tumour studies, helped to recognise activated phosphatidyl choline (PtdCho) metabolism as one emerging metabolic hallmark associated with oncogenesis and tumour progression (Podo, 1999; Podo et al, 2011).
At molecular level, the analysis of a collection of 27 GBM patients revealed that the unmethylation of bcl-2 gene is the only hallmark associated with a low level of genome methylation in the one hand and with a low intra-tumor apoptosis level in the other hand.
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The age of S-LAP clusters and the associated sequence divergence at these loci means that hallmarks associated with gene duplication mechanisms are often obscured, making gene duplication mechanisms difficult to infer.
The same mechanism also reproduces key behavioral hallmarks associated with target-distracter interactions.
More importantly, we identified potential molecular hallmarks associated with early pathological events of motor neuron with SOD1 +/ALS2C ALS mutation.
Thus, CDDP damage, in the absence of RB and p53, yielded a complex gene expression program that had hallmarks associated with a transformed/oncogenic phenotype.
We report here that astrocytic elevation of MAO-B in adult mice recapitulates many of the pathological hallmarks associated with human PD and that these effects can be prevented by treatment with the selective MAO-B inhibitor deprenyl or the antioxidant EUK189.
One of the hallmarks associated with chronological skin aging is an increase in inflammation.
We conclude that HuH7 and HuH6 HCC cells possess characteristic hallmarks associated with oncogene-induced senescence following depletion of MKL1/2.
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Justyna Jupowicz-Kozak
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