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But in this Hallmark age, when suburban streets are cloaked in orange from Labor Day to Thanksgiving, and the birthdays of Lincoln and Washington have merged into an entire week of blacked-out frequent flyer days, St. Patrick's Day has become the industrial Northeast's answer to Mardi Gras.
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Protein aggregation is a hallmark of aging and several age-related pathologies, collectively known as conformational diseases (CD) [ 4].
For instance, age-related mitochondrial dysfunction (another hallmark of aging) is coupled with reduced nuclear NAD+ level, the process of which is dependent on SIRT1.
We hypothesize that dysregulation of proteostasis as a hallmark of aging is of minor importance during lung aging, at least under conditions of healthy aging.
Collapse of proteostasis and accumulation of damaged macromolecules have been recognized as hallmarks of aging and age-related diseases.
Instability, denaturation and aggregation of proteins are hallmarks of aging and age-associated neurodegeneration [13].
It is considered a hallmark of aging and is also involved in the pathogenesis of certain age related pathologies such as macular degeneration [ 16].
(Fig. 9) Age-dependent impairment of learning and memory is a hallmark of aging in complex organisms and is observed in many model systems, including Drosophila [24].
Age-dependent up-regulation of GFAP is a well-characterized hallmark of aging in mammals (Riddle, 2007; Park et al., 2009).
Mitochondrial dysfunction is in fact a main hallmark of aging, which is partly caused by accumulation of mtDNA damage as we age (Lopez‐Otin et al., 2013).
The focus of the first part of the article is on recent studies using cell-derived decellularized ECM, which strongly suggest that age-related changes in the ECM induce cellular senescence, a well-recognized hallmark of aging.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com