It should be noted that the relatively high SE of the half-life estimates for the brain reflects the large interanimal variation in Hg concentrations at each sampling time, limited number of data points, and the short duration of sacrifice relative to the washout half-life.
This is not say that Half-Earth is a washout.
The first half of the year was not a washout for McIlroy, who posted four top-10 finishes, including a second at the Texas Open.
Extended observation over 3 min is important to characterize HCC by demonstrating eventual washout, as more than half of the washout occurs after a 90-s delay (Fig. 5).
Washout in late phase is observed in about half of HCC, but more rarely in small nodules (20 30% in those 1-2 cm, 40 60% in those 2-3 cm).
The two 4-week treatment periods (during which half of the subjects received GTE and the other half PL, and vice versa) were separated by a 4-week washout period.
Antiarrhythmic agents were discontinued before the procedure, allowing a washout period of five half-lives (except for amiodarone), while AV blocking agents were permitted in highly symptomatic patients.
The first 2 days of each treatment period will not be used to assess efficacy, to allow for washout of active medications (half-lives: MPH 4 hours; DEX 6 8 hours).
After a washout period of 1 week, one-half of the 40 highest and 40 lowest alcohol drinkers were challenged with a second dose of alcohol and the other half with saline.
Therefore, prior to screening and ECG recording, patients would have undergone a washout period equal to 5 half lives of their ongoing treatment.
This was a single-center, single-dose, open-label, randomized, 4-sequence, crossover study with a 3-week washout period (ie, >5 artemisinin half-lives) between occasions.
