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Surprisingly, we observed that reducing the gene dosage of rbf1 by half was sufficient to derepress Cyclin E expression at the MF (Fig. 4B).
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We conclude that SET8's N-terminal half is sufficient for its localization to laser micro-irradiation mediated DNA damage.
Only clozapine was used in experiment 2 and was injected at the same time point as in experiment 1. Ketamine injections and saline shams were administered half an hour before fear conditioning, as previous observations in our lab showed that half an hour was sufficient for ketamine-induced increases in locomotor activity to subside [61].
As a result, the upper range was limited, but the effective octave and a half that remained was sufficient for Renaissance music.
For both drugs, half the recommended dose was sufficient to inhibit the proliferation of more than 70% of hamster lymph node cells.
This is in line with the regulation reported for Pnmt (Phenylethanolamine-N-methyltransferase) and Amy2 in which binding of GR monomers to GREs or a GRE half-site (i.e. only one-half of the classical palindrome) was sufficient to confer induction by GCs [ 80, 81].
They found that neither the half-life nor the half diffusion length of OH was sufficient to traverse the membrane and inhibit the E. coli cells.
One and one-half min of NGF stimulation was sufficient to induce the latent process.
The C-terminal half of GCP-WD (C300) was sufficient for the interaction with Plk1 (Fig. 2D).
Thus, the 12 ns measurement time during the later half of 24 ns simulation was sufficient for monitoring the dynamics of contacts, We also observed transient formation of β-sheets, consistent with experiment.
Using the truncated versions of DNC-3 tagged with GST, we found that the C-terminal half of the DNC-3 was sufficient to interact with 6xHis-DNC-2, whereas both N-terminal and C-terminal regions of DNC-3 were required to interact with 6xHis-DNC-1 (Fig. 6B).
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