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The ratio of the geometric means for the area under the plasma concentration-time curve between paediatric and adult patients was 0.54 (90% CL : 0.37, 0.78), indicating that exposure to bosentan in children in the current study was half the exposure found in adult patients.
For images acquired at half the exposure time, the corresponding average intensity over the field of view was doubled for the quantification study.
To evaluate this approach, we estimated the impact of a hypothetical scenario where the population's exposure distribution is reduced by 50%; in other words, each child receives half the exposure he or she was previously getting.
The ratio of the geometric means for AUCt between paediatric and adult patients was 0.54 (95% CL 0.37, 0.78), indicating (i) that exposure to bosentan in children in the current study was half the exposure found in adult patients, and (ii) that the ratio was not within the predefined equivalence limits of 0.66 1.50.
"If we had half the exposure that M.L.B. gets, our sport would be huge, but we don't get the exposure".
We have found that 193nm lithography with this new family of photoresists is reasonably proficient in the fabrication of devices with design rules of less than half the exposure wavelength.
Similar(53)
In both cases more than half of the exposure was to Ireland's private sector, rather than lending to the government or Ireland's beleaguered banks.
In these subjects, at least half of the exposure duration falls within an etiologically relevant period.
But the E-R pattern is implausible from a biological standpoint because of the declines in the upper half of the exposure range.
C. elegans were incubated with the S. venezuelae metabolite for half the standard exposure time to enhance visualizing neuronal vulnerability to a secondary stressor, such as 6-OHDA, while not appreciably causing neurodegeneration with metabolite alone.
We found that only half of the exposures involved use of PPE.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com