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For this generation of IGRF, applying the same philosophy would have led to the rejection of more than half of the candidate models, including all of the physically based candidate models to the predictive SV-2015-2020 (see the possible set of weights summarized Table 8 that were discussed by the task force).
Exactly half of the candidate gene islands that were identified this way indeed contained (non-TE) coding sequences.
On average, nearly half of the candidate genes were polymorphic in all species, with the exception of P. mugo, where more than 70% of the genes displayed variation.
Using this approach, Karlsson et al. [ 24] were able to eliminate more than half of the candidate polymorphisms for a causative mutation involved in coat colour in dogs.
In the present study, we found two consecutive selection regions on OAR2 and 6 involving a total of 38 windows (11.4 Mb), which were almost half of the candidate selection regions of Duolang.
Nevertheless, one still has to expect many regions with no obvious coding capacity as half of the candidate gene islands on the de novo sequenced BACs harboured no genes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com