This may indicate that cyclin A overexpression is related to both tumor development and progression in approximately half of differentiated-type gastric cancers.
While roughly half of poorly differentiated, high-grade type I tumours exhibit TP53 mutations, low-grade tumours rarely display TP53 mutations, suggesting that loss of function of the p53 tumour suppressor protein is a late event in the progression of type I disease (Lax et al, 2000).
However, lack of washout should not be considered diagnostic of a benign lesion in a cirrhotic liver since approximately half of well-differentiated tumors fail to show washout.
Further, all well-differentiated DCISs were p53 negative, while half of the poorly differentiated lesions were p53 positive (P<0.001).
On the other hand, RAS mutations are also found in approximately one-half of poorly differentiated and anaplastic thyroid carcinomas and are associated with poor patient survival, suggesting that RAS may have distinct roles in the early and late stage of thyroid cancer [ 19, 20, 24].
In addition, approximately half of the differential miRNAs do not target any genes in the differentiated gene list.
The reported chondrichthyan catch has been increasingly dominated by rays, which have made up greater than half of reported taxonomically-differentiated landings for the past four decades.
Despite the intratumoural heterogeneity in Ki-67 labelling found in nearly half of metastatic well-differentiated NENs to the liver, Yang demonstrated that Ki-67 grading based on virtual biopsies had significant prognostic value similar to that using whole slides.
Based on the staining intensity, percentages of differentiated, half-differentiated and undifferentiated cells were determined by counting.
The remaining half of the treated plants differentiated into male.
Furthermore, half of the injected MSCs differentiated to NPC-like cells after 4 weeks of culture.
