However, these suffer from several shortcomings such as short half-life span, lesser fibrin specificity, higher therapeutic dose, allergic responses, substantial risk of bleeding complications and increased costs (Blann et al. 2002; Turpie et al. 2002).
Moreover, the lifespan of gram-negative bacteria is not more than six hours in vitro; the half-life span is less than an hour [ 22].
It modulates TGFβ receptors post-transcriptionally by affecting their mRNA stability, but does not change the Smad-3 and Smad-7 mRNA half-life span, suggesting a potential transcriptional effect on these genes.
In order to maximize the effect of rhBMP-2, it is crucial to standardize an ideal dose of rhBMP-2 for each of the different implant surfaces as well as to overcome a short half-life span of rhBMP-2.
The observed half-life span of rhBMP-2 in the present study was shorter than that in the previous study [ 25] where 0.75 mg/mL of rhBMP-2, coating anodized implant, released 36% of it on the first day of implant plantation and 67% of it in a week.
To unify the time unit, the half-life spans of all the drugs investigated were uniformly converted to minutes.
It is interesting to predict the metabolic stability of drug target proteins and compare the results with the half-life spans of the corresponding drugs.
For demonstration, the predicted metabolic stability outcomes for some drug target proteins and the real half-life spans of their corresponding drugs are given in the Table S3, from which we found some intriguing correlations.
He notes that almost 50% of the birds died before they had reached half the average life span, whereas in humans or mice, usually less than 10% of the population dies so young.
One standard is that the minimum age of a stand of trees must be about half the average maximum life span of the dominant species.
