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Moment tensor solutions colored based on their variance as a function of the half-duration of the source time function (Tr) and the centroid depth.

In Fig. 4, we show the distribution of waveform variance as a function of the half-duration of the source time function (Tr) and the centroid depth.

Finally, the half-duration of the TCR was plotted against the peak release rate (PRR).

In the high PRR limit, the half-duration of the TCR increased with PRR.

Numbers right-adjacent to the contour lines indicate peak release rate and half-duration of the TCR, respectively.

In the low PRR limit, the half-duration of the TCR decreased with PRR in a model with fixed coupling distance.

Whereas lowering the temperature had large effects on the absolute value of the half-duration of the TCR, its [Ca2+]o independence was unchanged.

Bottom, contour plots of peak release rate (left) and half-duration of the TCR (right), plotted vs coupling distance (horizontal axis) and Ca2+ inflow (vertical axis, normalized to that of single Ca2+ channel).

(B ) Plot of half-duration of the TCR vs peak release rate for different coupling distances in a model with reduced Ca2+-unbinding rate of the fixed buffer (koff, 40 s−1; Eggermann and Jonas, 2012 ).

(A ) Plot of half-duration of the TCR vs peak release rate for different coupling distances in a model with increased concentration of the endogenous fixed buffer (0.5 mM).

(C ) Plot of half-duration of the TCR vs peak release rate for different coupling distances (individual curves for 10 to 200 nm in 5 nm steps; scale bar for color in (A )).