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The percent inhibition at half concentration, IC50, values were determined for all inhibitors under the study and were estimated to be in the 5 30 nM range.
Reduction to almost half concentration (20 μM B, 0.7 μM M and 0.01 μM G) did not have significant effects, but addition of the histone deacetylase inhibitor suberoylanilide hydroxamic acid (0.6 μM) to this combination resulted in a marked (∼65%) growth inhibition.
The term apparent dissociation constant is used in place of the half concentration of excitation and inhibition.
Define the 'white point' as the mixture of all those odors at half concentration, that is, the odor vector w = (0.5,…,0.5).
Of note, 84.6% of embryos injected with half concentration of exon 9 morpholino exhibited the same phenotypic (both motor and morphologic) changes (n = 78, data not shown).
n = 9 flies for each analysis, 5 flies from the above traces and 4 flies from the same experiment at half concentration (data not shown).
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In another set of experiment cells were incubated with half concentrations of compounds and predinsalone was used as reference drug (control positive) with concentration of 10 μg/mL.
The rate equation for the transesterification reaction in the model system was modified using half-concentration of BEN, which is the only effective in the intermolecular exchange.
The mother reactor was fed with synthetic wastewater in half-concentration all the time, while the three SBRs were fed with the synthetic wastewater in half-concentration only during the first 34 days to model the wastewater at relative low concentrations, and then increased to full concentration from day 35 to represent the wastewater at relative high concentrations.
During stimulation, serum concentrations were half the concentrations used for maintenance culture.
The KT (one-half saturation concentration) for SVCT2 is ~50 μM [ 18, 19].
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