Adu, who set up Johnson with a pass late in the first half, was replaced by Clint Dempsey in the 70th minute.
Reference sires were picked from a team of six rams of which half were replaced each year.
O'Driscoll, who suffered a knee injury in the first half, was replaced at the break by David Kearney.
One half was replaced by a tricyclic aromatic group and there was only one stereogenic center present, but the rotation operated according to the same principles as the first generation motor 41.
The Wales back, starting at fly-half, was replaced after 30 minutes and taken immediately for an X-ray.
In this he was not alone though, as Tom Cleverley, who with Michael Carrick made up United's midfield trio, lasted just the first half before being replaced: against Yaya Touré, Fernandinho and David Silva, their inferiority was clear.
Winger Markovic played the first half before being replaced by Brazilian Philippe Coutinho.
That started a flurry of Sunderland chances and Fabio Borini forced two excellent fingertip saves from Marshall at the end of the first half before being replaced by Fletcher at the break because of illness.
Arteta, meanwhile, lasted a little more than half an hour, being replaced by Mathieu Flamini early in the second half.
Doherty did not emerge for the second half, being replaced with George Francomb, and the reorganised defence had no time to settle before Hibs went three behind two minutes after the break from Mulgrew's curling free-kick into the far corner from 22 yards.
