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Normally they have very low bioavailability," he says.
Furthermore, their insolubility in water and poor oil solubility at room temperature [1] cause them to have very low bioavailabilities, so only a minor fraction of the carotenoids found in raw fruits or vegetables is absorbed in the intestines [2, 3].
Pharmacokinetic analysis showed that linaclotide had very low oral bioavailability (0.1%), and was undetectable in the systemic circulation at therapeutic doses.
I had very low expectations.
Evening dresses had very low necklines.
This patient group had very low adherence.
Lubiprostone acts locally within the intestinal tract, is rapidly metabolized, and has very low systemic bioavailability.
Although effective clinically, tigecycline is reported to have very low oral bioavailability (5), which limits its use to intravenous administration in a hospital setting.
These factors, together with the fact that ciclesonide has very low oral bioavailability due to almost complete first pass metabolism[ 14] would seem to create conditions favouring the maximisation of therapeutic effect in the lung and minimisation of the risk of systemic adverse effects.
We have very low expectations.
Each has very low costs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com